This open access book presents how Open Science is a powerful tool to boost Higher Education. The book introduces the reader into Open Access, Open Technology, Open Data, Open Research results, Open Licensing, Open Accreditation, Open Certification, Open Policy and, of course, Open Educational Resources. It brings all these key topics from major players in the field experts that present the current state of the art and the forthcoming steps towards a useful and effective implementation. This book presents radical, transgenic solutions for recurrent and long-standing problems in higher education. It is called "transgenic" because the process is similar to the biological transgenic technique, metaphorically speaking, a specific item is taken out of a chain of parts, modified and put back on the chain, to make it better, faster, cheaper, or more personalized, or localized. This book is part of a trilogy with companion volumes on Radical Solutions and Learning analytics and Radical Solutions and eLearning.