We live in a time when the environment makes headlines, especially in association with global climate change and the potential human impact on the planet. It is remarkable that even now, with the environment becoming an important issue in world politics, we still do not really know how or to what extent our environment interacts with our brain and overall physiology. The environment is intricately and, from a research standpoint, hopelessly, multifactorial. The effects of global climate change may be readily seen not only in the thermoregulatory response to temperature fluctuation. This book discusses the environment and its influence on mood disorders and suicide from a scientific perspective.